Liver is a vital organ that performs several important bodily functions including bile production for digestion, protein production, synthesis of blood clotting factors, storage of glucose (sugar) in the form glycogen, and detoxification. Also, the liver cells have a remarkable ability to regenerate themselves after any damage. Due to this unique capability, the liver tissues have fascinated the researchers. True understanding of molecular and cellular connectivity and functions of the liver tissues in an in-vivo as well as in-vitro setting is very important from the viewpoint of discovery science and clinical application. Development of liver models that can provide a virtual ecosystem that mimics the molecular processes of a liver factory can help understand molecular interactions to network dynamics and whole organ functions. These advanced liver models are mini-organs or organoids that are expected to replicate human liver physiology, anatomy, and functions from molecular layer upward. The formation of these living models is a fairly new area of science that has the potential to replace animal models. The human liver models offer several advantages over animal models that are not always accurate and pose ethical issues. The human liver models or organoids have been used to screen new drugs for liver toxicity. These models are also being deeply studied to build a functional model of human liver development. The process of making a human liver model starts with a fetal liver progenitor cell, an immature cell that transforms into a specialized liver cell. The fetal liver progenitor cell is allowed to self-assemble in a small disc. These discs are composed of ferret liver cells that are pre-processed to remove all cells of the ferret. The resultant mini-organ models the actual human liver development. These models have been observed to generate hepatocytes, the basic functional cells of the liver, which is expected to produce the functional bioengineered liver tissues for transplantation into patients in the near future.
Due to the COVID-19 pandemic, the global Human Liver Models market size is estimated to be worth US$ 1568.2 million in 2021 and is forecast to a readjusted size of US$ 3359.4 million by 2028 with a CAGR of 11.0% during the forecast period 2022-2028. Fully considering the economic change by this health crisis, the Europe Human Liver Models market is estimated at US$ million in 2022, while the United States and China are forecast to reach US$ million and US$ million by 2028, respectively. The proportion of the United States is % in 2022, while Chinese percentage is %, and it is predicted that China market share will reach % in 2028, trailing a CAGR of % through the analysis period. As for the Europe Human Liver Models landscape, Germany is projected to reach US$ million by 2028. and in Asia, the notable markets are Japan and South Korea, CAGR is % and % respectively for the next 6-year period.
North American segment accounted for the largest share of the market in 2018. The human liver market for North America is driven by the presence of a well-established life sciences industry, growing awareness about the organoids technology, increasing government funding, growing incidence of NAFLD, and unavailability of livers for transplantation, increasing investments on research, rising focus on tissue culture-based clinical diagnostics, and the availability of skilled professionals.
This report focuses on Human Liver Models volume and value at the global level, regional level, and company level. From a global perspective, this report represents overall Human Liver Models market size by analysing historical data and future prospect. Regionally, this report focuses on several key regions: North America, Europe, China and Japan, etc.
Global Human Liver Models Market: Segment Analysis
The research report includes specific segments by region (country), by company, by Type and by Application. This study provides information about the sales and revenue during the historic and forecasted period of 2017 to 2028. Understanding the segments helps in identifying the importance of different factors that aid the market growth.
Segment by Type
Liver Organoids
Liver-on-a-chip
2D Models
3D Bioprinting
Others
Segment by Application
Drug Discovery
Education
Others
By Region
North America
U.S.
Canada
Europe
Germany
France
U.K.
Italy
Russia
Asia-Pacific
China
Japan
South Korea
India
Australia
Taiwan
Indonesia
Thailand
Malaysia
Philippines
Vietnam
Latin America
Mexico
Brazil
Argentina
Middle East & Africa
Turkey
Saudi Arabia
U.A.E
By Company
Emulate
Ascendance Bio
InSphero
CN Bio
Organovo
Cyfuse Biomedical
Mimetas